Endocrine Abstracts

Cimetidine, an H2 receptor antagonist, has been shown to be clinically valuable in the treatment of peptic ulcers. Recently, the effect of cimetidine on the reproductive system has been studied in detail and there are some reports showing the untoward effects of cimetidine on this system. In this paper was undertaken to evaluate the effect of cimetidine on serum testosterone, testes, prostate, seminal vesicle and vas deferens. Apart from the above objective,the mechanism throu...

The development of genital organs of rats chronically treated with cimetidine showed that the drug may present anti-androgenic activity. Rats were treated i.p. with cimetidine at a dose of 50 mg/kg body weight for 59 days. Accessory sex organ weights, were significantly reduced in the high dose treated groups. A high degree of variability characterized testis histology, with most tubules appearing normal and some tubules (15–17%) partially lacking or devoid of germ cells....

Cimetidine is a selective antagonist of histamine at gastric H2-receptor sites. A 24 month oral cimetidine toxicity and carcinogenicity study in rats at dose levels of 150, 378 and 950 mg/kg was performed. Cimetidine appeared to produce changes involving the liver and the male reproductive organs. In this paper non-tumour Leydig cell morphology was normal in cimetidine treated groups. It was concluded that the higher statistically significant incidence (apparent onl...